Axl Antibody - CD BioSciences

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Axl Antibody

Axl Antibody

SPA-00791

Size Price
0.1 mg Online Inquiry
More Options Online Inquiry
Target Information
Target Name Axl
Gene Abbr. AXL
Gene ID 558
Full Name AXL receptor tyrosine kinase
Alias ARK, JTK11, Tyro7, UFO
Introduction Axl, Mer and Tyro3 are three members of the TAM family receptor tyrosine kinase that share a common NCAM (neural adhesion molecule)-related extracellular domain and a conserved intracellular tyrosine kinase domain. These receptors bind common homologous vitamin K dependent protein GAS6 and protein S to activate downstream signaling pathways. TAM family receptors are involved in the development of immune, nervous, vascular and reproductive systems, autoimmune disease, cancer drug resistance and tumor immunity response. Axl (Tyr698), Axl (Tyr702), Mer Tyr(749) and Tyro3 (Tyr681) are conserved autophosphorylation sites located in the activation loop of the respective tyrosine kinase domains. Phosphorylation at these sites is required for full kinase activation of each of the corresponding receptors.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 6C8
Isotype IgG2A Kappa
Immunogen AXL (AAH32229, 30 a.a. ~ 140 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. TQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPY.
Usage
Application WB, ELISA, IHC
Dilutions Western Blot (1:500)
MW(KDa) 138
Reactivity Human
Specificity AXL - AXL receptor tyrosine kinase.
Storage & Handling
Storage Buffer In 1X PBS, pH 7.4.
Preservative No Preservative
Storage Temp. Aliquot and store at -20 °C or -80 °C.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.