Axin2 Antibody - CD BioSciences

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Axin2 Antibody

Axin2 Antibody

SPA-00790

Size Price
25 µL Online Inquiry
0.1 mL Online Inquiry
More Options Online Inquiry
Target Information
Target Name Axin2
Gene Abbr. AXIN2
Gene ID 8313
Full Name axin 2
Alias AXIL, ODCRCS
Introduction Axin1 (Axis inhibition protein 1) and Axin2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin1 interacts with APC, GSK-3β, Dvl, and β-catenin and promotes the GSK-3β-mediated phosphorylation and subsequent degradation of β-catenin. Upon stimulation of cells with Wnt, Axin1 is recruited to the membrane by phosphorylated LRP5/6, a process that is believed to be crucial for activation of Wnt signaling. In addition to its role in the Wnt signaling pathway, Axin1 forms a complex with MEKK1 and activates c-Jun amino-terminal kinase (JNK/SAPK). Axin2 (also known as Conductin or Axil) can functionally substitute for Axin1 in mice. Axin2 itself is a direct target of the Wnt signaling pathway and therefore serves to control the duration and/or intensity of Wnt signaling through a negative feedback loop.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. D48G4
Immunogen Synthetic peptide corresponding to residues surrounding Pro566 of human Axin2 protein.
Source/Purification Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro566 of human Axin2 protein.
Usage
Application WB, IP
Dilutions Western Blot (1:1000); Immunoprecipitation (1:200)
MW(KDa) 95, 98
Reactivity Human
Sensitivity Endogenous
Specificity It detects endogenous levels of total Axin2 protein.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.