Axin1 Antibody - CD BioSciences


Axin1 Antibody

Axin1 Antibody


Size Price
25 µL Online Inquiry
0.1 mL Online Inquiry
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Target Information
Target Name Axin1
Gene Abbr. AXIN1
Gene ID 8312
Full Name axin 1
Alias AXIN, PPP1R49
Introduction Axin1 (Axis inhibition protein 1) and Axin2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin1 interacts with APC, GSK-3β, Dvl, and β-catenin and promotes the GSK-3β-mediated phosphorylation and subsequent degradation of β-catenin. Upon stimulation of cells with Wnt, Axin1 is recruited to the membrane by phosphorylated LRP5/6, a process that is believed to be crucial for activation of Wnt signaling. In addition to its role in the Wnt signaling pathway, Axin1 forms a complex with MEKK1 and activates c-Jun amino-terminal kinase (JNK/SAPK). Axin2 (also known as Conductin or Axil) can functionally substitute for Axin1 in mice. Axin2 itself is a direct target of the Wnt signaling pathway and therefore serves to control the duration and/or intensity of Wnt signaling through a negative feedback loop.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. C95H11
Immunogen Recombinant protein of human Axin1.
Source/Purification Antibody is produced by immunizing animals with a recombinant protein of human Axin1.
Application WB, IP, IHC
Dilutions Western Blot (1:1000); Immunoprecipitation (1:50)
MW(KDa) 110
Reactivity Human, Monkey
Sensitivity Endogenous
Specificity It detects the endogenous levels of total Axin1 protein.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.