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ATM siRNA I
SPR-00178
| Size | Price |
| 1 Unit | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | ATM |
| Gene Abbr. | ATM |
| Gene ID | 472 |
| Full Name | ATM serine/threonine kinase |
| Alias | AT1, ATA, ATC, ATD, ATDC |
| Introduction | Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that regulates cell cycle checkpoints and DNA repair. Activation of ATM by autophosphorylation on Ser1981 occurs in response to exposed DNA double stranded breaks. ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair. Known substrates include p53, Chk2, Chk1, CtIP, 4E-BP1, BRCA1, RPA3, H2A.X, SMC1, FANCD2, Rad17, Artemis, Nbs1, and the I-2 regulatory subunit of PP1. Mutations in the corresponding ATM gene result in ataxia telangiectasia an autosomal recessive disease characterized by uncoordinated muscle movement and neurodegeneration. Cells from AT patients display defective DNA damage-induced checkpoint activation, sensitivity to radiation, and a higher frequency of chromosome breakage. |
| Usage | |
|---|---|
| Application | RNA interference |
| Reactivity | |
| Storage & Handling | |
|---|---|
| Storage Buffer | The siRNA product is supplied in RNAse-free water. |
| Storage Temp. | Aliquot and store at -20 °C. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.