β-Arrestin 1/2 Antibody - CD BioSciences

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β-Arrestin 1/2 Antibody

β-Arrestin 1/2 Antibody

SPA-12003

Size Price
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100 µg Online Inquiry
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Target Information
Target Name β-Arrestin 1
Gene Abbr. ARRB1
Gene ID 408
Full Name arrestin beta 2
Alias ARB1, ARR1
Introduction Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization of the receptor and desensitization of GPCR signaling. Four distinct mammalian arrestin proteins are known. Arrestin 1 (also known as S-arrestin) and arrestin 4 (X-arrestin) are localized to retinal rods and cones, respectively. Arrestin 2 (also known as β-arrestin 1) and arrestin 3 (β-arrestin 2) are ubiquitously expressed and bind to most GPCRs. β-arrestins function as adaptor and scaffold proteins and play important roles in other processes, such as recruiting c-Src family proteins to GPCRs in Erk activation pathways. β-arrestins are also involved in some receptor tyrosine kinase signaling pathways. Additional evidence suggests that β-arrestins translocate to the nucleus and help regulate transcription by binding transcriptional cofactors.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. D24H9
Immunogen Recombinant protein containing the carboxy-terminal region of human β-arrestin 1.
Source/Purification Antibody is produced by immunizing animals with a recombinant protein containing the carboxy-terminal region of human β-arrestin 1.
Usage
Application WB, IP
Dilutions Western Blot (1:1000); Immunoprecipitation (1:200)
MW(KDa) 50
Reactivity Human, Mouse, Rat, Monkey
Sensitivity Endogenous
Specificity It detects endogenous level of total beta-arrestin 1 and beta-arrestin 2 proteins.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.