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APS Antibody
SPA-06809
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Kallikrein |
| Gene Abbr. | KLK3 |
| Gene ID | 354 |
| Full Name | kallikrein related peptidase 3 |
| Alias | APS, KLK2A1, PSA, hK3 |
| Introduction | APS is an SH2 and PH domain-containing adaptor protein closely related to Lnk and SH2-B. APS was identified as a substrate for many receptor tyrosine kinases including TrkA, insulin receptor, c-Kit and PDGF receptor. Tyrosine phosphorylation of APS provides docking sites for downstrean signaling components, mediating diverse signaling pathways. APS plays quite different roles in RTK signaling. Overexpression of APS has been shown to inhibit PDGF-induced mitogenicity, which may result from APS/c-Cbl-mediated PDGF receptor degradation. However, APS promotes enhanced mitogenicity in response to insulin stimulation. The striking difference in APS-mediated signaling between the different RTKs could lie in the mode of interaction with the respective receptor. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Immunogen | Synthetic peptide corresponding to residues near the amino-terminus of human APS. |
| Source/Purification | Antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino-terminus of human APS. Antibodies are purified by protein A and peptide affinity chromatography. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (1:1000) |
| MW(KDa) | 90-95 |
| Reactivity | Human, Mouse |
| Sensitivity | Endogenous |
| Specificity | This antibody detects endogenous levels of total APS. This antibody does not cross-react with other adaptor/docking proteins. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol. |
| Preservative | No Preservative |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.