Activin RIIA Antibody - CD BioSciences

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Activin RIIA Antibody

Activin RIIA Antibody

SPA-00187

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100 µg Online Inquiry
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Target Information
Target Name Activin Receptor
Gene Abbr. ACVR2A
Gene ID 92
Full Name activin A receptor type 2A
Alias ACTRII, ACVR2
Introduction Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. To date, seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActR-I(A), ActR-IB, ActR-II(A) and ActR-IIB, have been cloned from mammals. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated, adding to the complexity of the activin receptor system. Different activin isoforms bind with different high-affinities to the various type II isoforms. Type I activin receptors do not bind directly to activin, but will associate with the type II receptor-activin complex and initiate signal transduction. Besides the activin isoforms, ActR-II will also bind inhibin, BMP-2 and BMP-7 with lower affinities. ActR-I can also bind and form signaling complexes with the BMP-2/7-bound BMPR-II. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% amino acid sequence homology. Recombinant soluble activin type II receptors bind activin with high affinity, and are potent activin antagonists.
Product Details
Host Goat
Clonality Polyclonal
Clone No. N/A
Isotype IgG
Immunogen S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Activin RIIA. Ser25-Asp82. Accession # P27037.
Usage
Application WB, IHC
Dilutions Western Blot (0.1 µg/mL); Immunohistochemistry (5-15 µg/mL)
Reactivity Human
Specificity Detects human Activin RIIA in direct ELISAs and Western Blots. In direct ELISAs and Western Blots, less than 2% cross-reactivity with recombinant human Activin RIIB is observed.
Storage & Handling
Storage Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative No Preservative
Storage Temp. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Handling Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

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