α-Actinin Antibody - CD BioSciences

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α-Actinin Antibody

α-Actinin Antibody

SPA-00180

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0.02 mg Online Inquiry
0.1 mg Online Inquiry
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Target Information
Target Name Actin
Gene Abbr. ACTN3
Gene ID 89
Full Name actinin alpha 3 (gene/pseudogene)
Alias ACTN3D
Introduction α-Actinin belongs to the spectrin family of cytoskeletal proteins. It was first recognized as an actin cross-linking protein, forming an antiparallel homodimer with an actin binding head at the amino terminus of each monomer. The α-actinin protein interacts with a large number of proteins involved in signaling to the cytoskeleton, including those involved in cellular adhesion, migration, and immune cell targeting. The interaction of α-actinin with intercellular adhesion molecule-5 (ICAM-5) helps to promote neurite outgrowth. In osteoblasts, interaction of α-actinin with integrins stabilizes focal adhesions and may protect cells from apoptosis. The cytoskeletal α-actinin isoforms 1 and 4 (ACTN1, ACTN4) are non-muscle proteins that are present in stress fibers, sites of adhesion and intercellular contacts, filopodia, and lamellipodia. The muscle isoforms 2 and 3 (ACTN2, ACTN3) localize to the Z-discs of striated muscle and to dense bodies and plaques in smooth muscle.
Product Details
Host Rabbit
Clonality Polyclonal
Clone No. N/A
Immunogen Synthetic peptide corresponding to carboxy-terminal residues of human α-actinin-1.
Source/Purification Antibodies are produced by immunizing animals with a synthetic peptide corresponding to carboxy-terminal residues of human α-actinin-1.
Usage
Application WB, IF
Dilutions Western Blot (1:1000)
MW(KDa) 100
Reactivity Human, Mouse, Rat, Hamster, Monkey
Sensitivity Endogenous
Specificity This antibody detects endogenous levels of total α-actinin protein.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol.
Preservative No Preservative
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.