ACTH Antibody - CD BioSciences

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ACTH Antibody

ACTH Antibody

SPA-00158

Size Price
0.02 mg Online Inquiry
0.1 mg Online Inquiry
More Options Online Inquiry
Target Information
Target Name ACTH
Gene Abbr. POMC
Gene ID 5443
Full Name proopiomelanocortin
Alias ACTH, CLIP, LPH, MSH, NPP
Introduction This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. SPM501
Isotype IgG1
Immunogen Synthetic peptide corresponding to aa25-39 of human ACTH (NGAEDESAEAFPLEF).
Usage
Application ELISA, FC, IF, IHC
Dilutions ELISA (1:100-1:2000); Flow Cytometry (0.5-1 µg/10^6 cells); Immunofluorescence (1-2 µg/mL)
Reactivity Human
Storage & Handling
Storage Buffer 10 mM PBS with 0.05% BSA.
Preservative 0.05% Sodium Azide
Storage Temp. Store at 4 °C.

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