Acetyl-CoA Carboxylase Antibody - CD BioSciences

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Acetyl-CoA Carboxylase Antibody

Acetyl-CoA Carboxylase Antibody

SPA-00136

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Target Information
Target Name ACC
Gene Abbr. ACACA
Gene ID 31
Full Name acetyl-CoA carboxylase
Alias ACAC, ACACAD, ACC, ACC1, ACCA
Introduction Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to malonyl-CoA. It is the key enzyme in the biosynthesis and oxidation of fatty acids. In rodents, the 265 kDa ACC1 (ACCα) form is primarily expressed in lipogenic tissues, while 280 kDa ACC2 (ACCβ) is the main isoform in oxidative tissues. However, in humans, ACC2 is the predominant isoform in both lipogenic and oxidative tissues. Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC. ACC is a potential target of anti-obesity drugs.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. C83B10
Immunogen Synthetic peptide corresponding to residues surrounding Ser523 of human acetyl-CoA carboxylase α1.
Source/Purification Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser523 of human acetyl-CoA carboxylase α1.
Usage
Application WB, IP, IF, IHC, FC
Dilutions Western Blot (1:1000); Immunoprecipitation (1:100)
MW(KDa) 280
Reactivity Human, Mouse, Rat, Hamster
Sensitivity Endogenous
Specificity It detects endogenous levels of all isoforms of acetyl-CoA carboxylase protein.
Storage & Handling
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide.
Preservative Less than 0.02% Sodium Azide
Storage Temp. Store at -20 °C.
Handling Do not aliquot the antibody.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.