4E-BP1 Antibody - CD BioSciences

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4E-BP1 Antibody

4E-BP1 Antibody

SPA-00092

Size Price
25 µg Online Inquiry
100 µg Online Inquiry
More Options Online Inquiry
Target Information
Target Name 4EBP
Gene Abbr. EIF4EBP1
Gene ID 1978
Full Name eukaryotic translation initiation factor 4E binding protein 1
Alias 4E-BP1, 4EBP1, BP-1, PHAS-I
Introduction Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity. Multiple 4E-BP1 residues are phosphorylated in vivo. While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E-BP1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. 7
Isotype IgG
Immunogen This antibody was obtained from a rabbit immunized with purified, recombinant Human 4EBP1 (NP_004086.1; Ser2-Ile118).
Usage
Application IF
Dilutions Immunofluorescence (1:20-1:100)
MW(KDa) 15-20
Reactivity Human
Storage & Handling
Storage Buffer 0.2 µm filtered solution in PBS.
Preservative No Preservative
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

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