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3-Methyladenine (3-MA)
SPC-00050
CAS No. 5142-23-4
| Size | Price |
| 50 mg | Online Inquiry |
| 500 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
PI3K inhibitor ; Autophagy inhibitor ; Mitophagy inhibitor
| Description |
|---|
| 3-Methyladenine (3-MA, NSC 66389) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. 3-Methyladenine (3-MA) is successfully used to suppress mitophagy. Solutions of 3-MA are best fresh-prepared by heating. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 5142-23-4 |
| Description | 3-Methyladenine (3-MA, NSC 66389) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. 3-Methyladenine (3-MA) is successfully used to suppress mitophagy. Solutions of 3-MA are best fresh-prepared by heating. |
| Formula | C6H7N5 |
| Molecular Weight | 149.15 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| Synonyms | NSC 66389 |
| SMILES | CN1C=NC(=N)C2=C1N=CN2 |
| Solubility | DMSO |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.