Cat#: CCR-0167
Pomalidomide-PEG5-azide
Synonyms (s): 17-Azido-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12,15-pentaoxaheptadecanamide, Crosslinker−E3 Ligase ligand conjugate, Pomalidomide conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader
Empirical Formula (Hill Notation): C25H32N6O10
Size: 50 mg
Product Introduction
| Molecular Weight | 576.56 |
| Assay | ≥95% |
| Form | Powder |
| Reaction Suitability | Reaction type: click chemistry |
| Smiles String | O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)NC1=O |
| Storage Temp. | 2-8 °C |
Application
Protein degrader builiding block Pomalidomide-PEG5-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Safety Information
| Storage Class Code | 11 - Combustible Solids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
