Cat#: CCR-0084
Alkyne-PEG4-maleimide, 90% (HPLC)
Synonyms (s): Acetylene-PEG4-maleimide
Empirical Formula (Hill Notation): C18H26N2O7
Size: 10 mg; 25 mg
Product Introduction
| Molecular Weight | 382.41 |
| NACRES | NA.22 |
| MDL Number | MFCD22380740 |
| PubChem Substance ID | 329767106 |
| Assay | 90% (HPLC) |
| Form | Liquid |
| Reaction Suitability | Reaction type: click chemistry |
| Smiles String | O=C(N1CCC(NCCOCCOCCOCCOCC#C)=O)C=CC1=O |
| InChI | 1S/C18H26N2O7/c1-2-8-24-10-12-26-14-15-27-13-11-25-9-6-19-16(21)5-7-20-17(22)3-4-18(20)23/h1,3-4H,5-15H2,(H,19,21) |
| InChI key | GHEBECZRHJXPTL-UHFFFAOYSA-N |
| Storage Temp. | -20 °C |
Application
Alkyne-PEG4-maleimide has been used for modification of Csy containing bacterial collagens by introducing alkyne moiety to enable it for further chemical modification.
Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.
Safety Information
| Storage Class Code | 10 - Combustible liquids |
| WGK | WGK 3 |
For research use only. Not for clinical use.
