Pomalidomide-PEG4-Alkyne

Synonyms (s): N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-4,7,10,13-tetraoxahexadec-15-ynamide, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader

Empirical Formula (Hill Notation): C₂₅H₂₉N₃O₉

Size: 50 mg

Product Introduction

Molecular Weight	515.51
NACRES	NA.22
Form	Powder or Crystals
Reaction Suitability	Reaction type: click chemistry
Smiles String	O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCOCCOCCOCCOCC#C)=O)=O)NC1=O
Storage Temp.	2-8 °C

Application

Protein degrader builiding block Pomalidomide-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Safety Information

Storage Class Code	13 - Non Combustible Solids
WGK	WGK 3

For research use only. Not for clinical use.