Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester

Synonyms (s): DBCO-PEG4-NHS ester, DBCO-PEG4-SE, DBCO-PEG4-succinimidyl ester

Empirical Formula (Hill Notation): C₃₄H₃₉N₃O₁₀

Size: 1 mg; 5 mg

Product Introduction

Molecular Weight	649.69
NACRES	NA.22
MDL Number	MFCD26793797
PubChem Substance ID	329767092
Assay	95%
Form	Paste
Reaction Suitability	Reaction type: click chemistry
Smiles String	O=C(CCC(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4
InChI	1S/C34H39N3O10/c38-30(11-12-31(39)36-25-28-7-2-1-5-26(28)9-10-27-6-3-4-8-29(27)36)35-16-18-44-20-22-46-24-23-45-21-19-43-17-15-34(42)47-37-32(40)13-14-33(37)41/h1-8H,11-25H2,(H,35,38)
InChI key	RRCXYKNJTKJNTD-UHFFFAOYSA-N
Storage Temp.	-20 °C

Application

Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester may be used in the synthesis of a prostate-specific membrane antigen (PSMA)-targeted single photon emission computed tomography (SPECT) agent via copper-less click chemistry.
Succinimidyl ester (NHS, amine reactive) functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free click chemistry cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. Applications Include: Protein-peptide conjugatesAntibody-enzyme or antibody-drug conjugatesProtein or peptide-oligonucleotide conjugates Surface modification

Safety Information

Storage Class Code	11 - Combustible Solids
WGK	WGK 3

For research use only. Not for clinical use.