BocNH-PEG5-acid

Synonyms (s): 2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid, Boc-NH-PEG5-CH2COOH

Empirical Formula (Hill Notation): C₁₇H₃₃NO₉

Size: 250 mg; 1 g

Product Introduction

Molecular Weight	395.45
CAS Number	890152-41-7
Form	Solid or Viscous liquid
Reaction Suitability	Reaction type: Pegylations; Reagent type: Cross-linking reagent
Smiles String	OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
Storage Temp.	-20 °C

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Safety Information

Storage Class Code	12 - Non Combustible Liquids
WGK	WGK 3

For research use only. Not for clinical use.