Cat#: CLP-0134
Amino-PEG4-t-butyl ester
Synonyms (s): tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, H2N-PEG4-CH2CH2COOtBu, H2N-dPEG(4)-CO-OtBu
Empirical Formula (Hill Notation): C15H31NO6
Size: 250 mg; 1 g
Product Introduction
Molecular Weight | 321.41 |
CAS Number | 581065-95-4 |
MDL Number | MFCD11041116 |
Form | Solid or Viscous liquid |
Reaction Suitability | Reagent type: Cross-linking reagent |
Smiles String | NCCOCCOCCOCCOCCC(OC(C)(C)C)=O |
Storage Temp. | -20 °C |
Application
This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
Safety Information
Storage Class Code | 12 - Non Combustible Liquids |
WGK | WGK 3 |
For research use only. Not for clinical use.