NCBI Accession #
NP_180944.2
NCBI GenBank Nucleotide #
NM_128948.4
NCBI Official Full Name
homeobox-3
NCBI Official Symbol
HB-3
NCBI Official Synonym Symbols
homeobox-3; STIMPY; STIP; T1B8.31; T1B8_31; WOX9; WOX9A; WUSCHEL related homeobox 9A; WUSCHEL-RELATED HOMEOBOX 9
NCBI Protein Information
homeobox-3
NCBI Summary
Encodes a protein with similarity to WUS type homeodomain protein. Required for meristem growth and development and acts through positive regulation of WUS. Loss of function phenotypes include embryo lethality, hyponastic cotyledons, reduced root development and smaller meristems. Phenotypes can be rescued by addition of sucrose in the growth media. Overexpression can partially rescue the triple mutant cytokinin receptor phenotype suggesting HB-3 is a downstream effector of cytokinin signaling.
UniProt Protein Name
WUSCHEL-related homeobox 9
UniProt Synonym Protein Names
Protein STIMPY
UniProt Primary Accession #
Q6X7J4
UniProt Secondary Accession #
O23662; Q8GX13
UniProt Related Accession #
Q6X7J4
UniProt Comments
Homeodomain transcription factor required for meristem growth and early development (PubMed:15753038). Promotes cell proliferation and prevents premature differentiation in meristematic tissues during postembryonic development (PubMed:15753038). Essential for maintaining tissue growth during embryogenesis (PubMed:17706632). May act by repressing TSS to promote meristematic proliferation (PubMed:21185286). Involved in the transcriptional activation of a subset of cytokinin response factors (PubMed:20110319). May act as a negative regulator of cytokinin signaling in the dark (PubMed:21057190).