WPP domain-interacting tail-anchored protein 2 (WIT2), Recombinant Protein
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WPP domain-interacting tail-anchored protein 2 (WIT2), Recombinant Protein

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Cat: RP03463
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana WPP domain-interacting tail-anchored protein 2 (WIT2) , partial
Product Gene Name
WIT2 recombinant protein
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
66,440 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
WPP domain-interacting tail-anchored protein

NCBI/Uniprot Data

NCBI Accession #
NP_001077797.1
NCBI GI #
145327191
NCBI GenBank Nucleotide #
NM_001084328.2
NCBI GeneID
843224
NCBI Official Full Name
WPP domain-interacting protein 2
NCBI Official Symbol
WIT2
NCBI Official Synonym Symbols
T6L1.9; T6L1_9; WPP domain-interacting protein 2
NCBI Protein Information
WPP domain-interacting protein 2
NCBI Summary
Encodes one of the WPP domain-interacting proteins (WIT1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WIT1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells.
UniProt Gene Name
WIT2
UniProt Protein Name
WPP domain-interacting tail-anchored protein 2
UniProt Primary Accession #
A8MQR0
UniProt Secondary Accession #
Q9CAB0
UniProt Related Accession #
A8MQR0
UniProt Comments
Together with WIT1, required for the nuclear envelope docking of RANGAP proteins in root tips (PubMed:18591351). Plays a role in nuclear shape determination (PubMed:25759303). As component of the SUN-WIP-WIT2-KAKU1 complex, mediates the transfer of cytoplasmic forces to the nuclear envelope (NE), leading to nuclear shape changes (PubMed:25759303).

For research use only, not for clinical use.