NCBI Accession #
NP_179370.2
NCBI GenBank Nucleotide #
NM_127333.5
NCBI Official Full Name
vacuolar protein sorting-associated 35A-like protein
NCBI Official Symbol
VPS35A
NCBI Official Synonym Symbols
T17A5.7; T17A5_7; VPS35 homolog A; ZIG suppressor 3; ZIP3
NCBI Protein Information
vacuolar protein sorting-associated 35A-like protein
NCBI Summary
Encodes a protein with similarity to yeast VPS35 which encodes a component of the retromer involved in retrograde endosomal transport. Mutants partially suppress the loss of VTI11 function in Arabidopsis and restores gravitropism in the double mutant.
UniProt Synonym Gene Names
ZIP3
UniProt Protein Name
Vacuolar protein sorting-associated protein 35A
UniProt Synonym Protein Names
Protein ZIG SUPPRESSOR 3; Vesicle protein sorting 35A
UniProt Primary Accession #
Q7X659
UniProt Secondary Accession #
Q0WMP3
UniProt Related Accession #
Q7X659
UniProt Comments
Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. Also involved in the efficient sorting of seed storage proteins (Probable). Binds alone to endosomal membranes and is required for recruitment of VPS26 and VPS29 to membrane (PubMed:23362252). The VPS29-VPS26-VPS35 subcomplex may be involved in recycling of specific cargos from endosome to the plasma membrane (PubMed:20086190).