NCBI Accession #
NP_565625.1
NCBI GenBank Nucleotide #
NM_128211.4
NCBI Official Full Name
uroporphyrinogen-III synthase family protein
NCBI Official Symbol
HEMD
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA UROPORPHYRINOGEN III SYNTHASE; ATDUF3; ATUROS; DOMAIN OF UNKNOWN FUNCTION 724 3; DUF3; T9J22.21; T9J22_21; UROPORPHYRINOGEN III SYNTHASE; UROS
NCBI Protein Information
uroporphyrinogen-III synthase family protein
NCBI Summary
Encodes a uroporphyrinogen-III synthase involved in tetrapyrrole biosynthesis. The protein localizes to the chloroplast. Member of the plant-specific DUF724 protein family. Arabidopsis has 10 DUF724 proteins. Loss of function mutant has a WT phenotype
UniProt Synonym Gene Names
HEMD; AtUROS
UniProt Protein Name
Uroporphyrinogen-III synthase, chloroplastic
UniProt Synonym Protein Names
Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase
UniProt Primary Accession #
O48721
UniProt Secondary Accession #
Q8LBE8; Q8RVZ2; Q8VZ12
UniProt Related Accession #
O48721
UniProt Comments
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, a precursor of tetrapyrroles such as chlorophyll, heme and phycobilins.