NCBI Accession #
NP_172527.2
NCBI GenBank Nucleotide #
NM_100932.4
NCBI Official Full Name
Cysteine proteinases superfamily protein
NCBI Official Symbol
OTS2
NCBI Official Synonym Symbols
OVERLY TOLERANT TO SALT 2; T10O24.20; T10O24_20; UB-LIKE PROTEASE 1C; ULP1C
NCBI Protein Information
Cysteine proteinases superfamily protein
NCBI Summary
Encodes a deSUMOylating enzyme. In vitro it has both peptidase activity and isopeptidase activity: it can cleave the C-terminal residues from SUMO to activate it for attachment to a target protein and it can also act on the isopeptide bond between SUMO and another protein. sYFP:OTS2 protein accumulates in nuclei in a punctate pattern. Double mutant analysis with ULP1D/OTS1 indicates that these genes are involved in salt stress responses and flowering time regulation.
UniProt Synonym Gene Names
OTS2
UniProt Protein Name
Ubiquitin-like-specific protease 1C
UniProt Synonym Protein Names
Protein OVERLY TOLERANT TO SALT 2
UniProt Primary Accession #
Q8RWN0
UniProt Secondary Accession #
Q3EDF1; Q9XIJ4
UniProt Related Accession #
Q8RWN0
UniProt Comments
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins. Cleaves precursors of SUM1 and SUM2, but not of SUM3 or SUM5. Able to release SUM1 and SUM2 from conjugates, but unable to cleave SUM3. Protease activity mainly directed at deconjugating SUM1 and SUM2 from their target proteins. Regulates salt stress responses and flowering time. Redundant with ULP1D.