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Ubiquitin-conjugating enzyme E2 variant 1C (UEV1C), Recombinant Protein
Cat: RP06077
Size: 0.02 mg (E-Coli)/ 0.1 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 1 mg (E-Coli)/ 0.1 mg (Baculovirus)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Ubiquitin-conjugating enzyme E2 variant 1C (UEV1C)
Product Gene Name
UEV1C recombinant protein
Product Synonym Gene Name
UEV1C
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MTLGSGSSVV VPRNFRLLEE LERGEKGIGD GTVSYGMDDG DDIYMRSWTG TIIGPHNTVH EGRIYQLKLF CDKDYPEKPP TVRFHSRINM TCVNHDTGVV DSKKFGVLAN WQRQYTMEDI LTQLKKEMAA SHNRKLVQPP EGTFF
Sequence Positions
1-145, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
16,382 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Ubiquitin-conjugating enzyme
NCBI/Uniprot Data
NCBI Accession #
NP_001078011.1
NCBI GI #
145330372
NCBI GenBank Nucleotide #
NM_001084542.1
NCBI GeneID
818179
NCBI Official Full Name
MMS ZWEI homologue 3
NCBI Official Symbol
MMZ3
NCBI Official Synonym Symbols
F11F19.3; F11F19_3; MMS ZWEI homologue 3; UBIQUITIN E2 VARIANT 1C; UEV1C
NCBI Protein Information
MMS ZWEI homologue 3
NCBI Summary
MMZ3/UEV1C encodes a protein that may play a role in DNA damage responses and error-free post-replicative DNA repair by participating in lysine-63-based polyubiquitination reactions. UEV1C can form diubiquitin and triubiquitin chains in combination with UBC13A/UBC35 in vitro. It can also functionally complement an mms2 mutation in budding yeast, both by increasing mms2 mutant viability in the presence of the DNA damaging agent MMS, and by reducing the rate of spontaneous DNA mutation. It can also rescue an mms2 ubc13 double mutant in yeast in combination with UBC13A. MMZ3/UEV1C transcripts are found at moderate levels in most plant organs, but cannot be detected in the pollen or 2 days after germination. Transcript levels do not appear to be stress-inducible.
UniProt Gene Name
UEV1C
UniProt Synonym Gene Names
MMZ3; Ubc enzyme variant 1C
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 variant 1C
UniProt Synonym Protein Names
Protein MMS ZWEI HOMOLOG 3
UniProt Primary Accession #
Q9SJ44
UniProt Secondary Accession #
Q3EBM3; A8MQX2
UniProt Related Accession #
Q9SJ44
UniProt Comments
Has no ubiquitin ligase activity on its own. The heterodimer with UBC catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. May play a role in the control of progress through the cell cycle and differentiation. May play a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
For research use only, not for clinical use.