NCBI Accession #
NP_001324961.1
NCBI GenBank Nucleotide #
NM_001336916.1
NCBI Official Full Name
WD-40 repeat family protein / small nuclear ribonucleoprotein Prp4p-like protein
NCBI Official Synonym Symbols
EMB2776; LACHESIS; T26J13.9; T26J13_9
NCBI Protein Information
WD-40 repeat family protein / small nuclear ribonucleoprotein Prp4p-like protein
NCBI Summary
Encodes LACHESIS (LIS), a protein with seven WD40 repeats. LIS is homologous to the yeast splicing factor PRP4 which is associated with the U4/U6 complex of the spliceosome. LIS is involved in a mechanism that prevents accessory cells from adopting gametic cell fate: lis mutant forms supernumerary egg cells.
UniProt Protein Name
U4/U6 small nuclear ribonucleoprotein PRP4-like protein
UniProt Synonym Protein Names
Protein EMBRYO DEFECTIVE 2776
UniProt Primary Accession #
O22212
UniProt Secondary Accession #
Q0WNB5; Q7GAP3; Q7Y1Z3
UniProt Related Accession #
O22212
UniProt Comments
Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome . Essential for reproduction. In female gametophyte, is necessary for the egg cell and central cell fate determination and hence reproductive success. Involved in a mechanism that prevents accessory cells from adopting gametic cell fate (PubMed:17326723). Modulates egg cell signaling center that regulates the development of all female gametophytic cells (PubMed:22190635).