NCBI Accession #
NP_568446.2
NCBI GenBank Nucleotide #
NM_122355.4
NCBI Official Full Name
two-component response regulator-like protein
NCBI Official Symbol
PRR5
NCBI Official Synonym Symbols
APRR5; pseudo-response regulator 5; T31K7.5; T31K7_5
NCBI Protein Information
two-component response regulator-like protein
NCBI Summary
Encodes a pseudo-response regulator whose mutation affects various circadian-associated biological events such as flowering time in the long-day photoperiod conditions, red light sensitivity of seedlings during early photomorphogenesis, and the period of free-running rhythms of certain clock-controlled genes including CCA1 and APRR1/TOC1 in constant white light. Acts as transcriptional repressor of CCA1 and LHY.
UniProt Protein Name
Two-component response regulator-like APRR5
UniProt Synonym Protein Names
Pseudo-response regulator 5
UniProt Primary Accession #
Q6LA42
UniProt Secondary Accession #
Q9FGE3; F4KH52
UniProt Related Accession #
Q6LA42
UniProt Comments
Transcriptional repressor of CCA1 and LHY, thereby controlling photoperiodic flowering response. Involved in the positive and negative feedback loops of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. Proteolytic substrate of the E3 ubiquitin ligase SCF(ADO1) complex. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock. Negative regulator of shade avoidance response. Involved in the inhibition of leaf expansion in shade avoidance response.