NCBI Accession #
NP_567495.1
NCBI GenBank Nucleotide #
NM_117737.5
NCBI Official Full Name
ADA2 2B
NCBI Official Symbol
ADA2B
NCBI Official Synonym Symbols
DL4235C; FCAALL.57; homolog of yeast ADA2 2B; PROPORZ1; PRZ1
NCBI Protein Information
ADA2 2B
NCBI Summary
Transcriptional co-activator. Essential for the developmental switch from cell proliferation to cell differentiation in response to variations in auxin and cytokinin concentrations.
UniProt Synonym Gene Names
PRZ1; AtADA2b
UniProt Protein Name
Transcriptional adapter ADA2b
UniProt Synonym Protein Names
Protein PROPORZ 1
UniProt Primary Accession #
Q9ATB4
UniProt Secondary Accession #
O23486; Q3EA06; Q3EA07
UniProt Related Accession #
Q9ATB4
UniProt Comments
Required for the function of some acidic activation domains, which activate transcription from a distant site. The exact mechanism of action is not yet known . ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region. Mediates auxin and cytokinin signals in the control of cell proliferation and might be involved in repression of a freezing tolerance pathway at warm temperature (PubMed:12615937, PubMed:12747832). Involved in the positive regulation of salt-induced gene expression by maintaining locus-specific acetylation of histones H4 and H3 (PubMed:21193996).