NCBI Accession #
NP_001185302.1
NCBI GenBank Nucleotide #
NM_001198373.2
NCBI Official Full Name
basic helix-loop-helix (bHLH) DNA-binding superfamily protein
NCBI Official Symbol
EGL3
NCBI Official Synonym Symbols
AtEGL3; ATMYC-2; EGL1; ENHANCER OF GLABRA 3; F24D7.16; F24D7_16
NCBI Protein Information
basic helix-loop-helix (bHLH) DNA-binding superfamily protein
NCBI Summary
Mutant has reduced trichomes, anthocyanin, and seed coat mucilage and abnormally patterned stomates. Encodes a bHLH Transcription Factor 1. The protein is functionally redundant with GL3 and TT8 and interacts with TTG1, the myb proteins GL1, PAP1 and 2, CPC and TRY, and it will form heterodimers with GL3. Expression in N (non-hair cell forming) cell layers is negatively regulated by WER. Expression in H cells (hair cell forming) is promoted by CPC/TRY.
UniProt Synonym Gene Names
EGL1; EGL3; EN30; MYC146; AtMYC146; AtbHLH2; bHLH 2
UniProt Protein Name
Transcription factor EGL1
UniProt Synonym Protein Names
Basic helix-loop-helix protein 2; AtMYC146; AtbHLH2; bHLH 2; Protein ENHANCER OF GLABRA 3; Transcription factor EN 30; bHLH transcription factor bHLH002
UniProt Primary Accession #
Q9CAD0
UniProt Secondary Accession #
O22418
UniProt Related Accession #
Q9CAD0
UniProt Comments
Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation but promotes trichome formation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Seems also to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Involved in seed mucilage production. Activates the transcription of GL2.