NCBI Accession #
NP_175399.2
NCBI GenBank Nucleotide #
NM_103864.2
NCBI Official Full Name
basic helix-loop-helix (bHLH) DNA-binding superfamily protein
NCBI Official Symbol
RGE1
NCBI Official Synonym Symbols
F14J22.2; F14J22_2; RETARDED GROWTH OF EMBRYO 1; ZHOUPI; ZOU
NCBI Protein Information
basic helix-loop-helix (bHLH) DNA-binding superfamily protein
NCBI Summary
Encodes a member of the basic helix loop helix family of transcription factors. Loss of RGE1 function causes shriveled seeds that contain small embryos. The cuticle in the embryos does not develop normally, possible due to the adeherence of the endosperm to the developing embryo. RGE1 is expressed in the endosperm surrounding region which directly surrounds the developing embryo, however it exerts its effect non autonomously- in the developing embryo. Mutant seedlings are extremely sensitive to dessication due to the abnormal cuticle.
UniProt Synonym Gene Names
bHLH 95
UniProt Protein Name
Transcription factor bHLH95
UniProt Synonym Protein Names
Basic helix-loop-helix protein 95
UniProt Primary Accession #
Q9FXA3
UniProt Related Accession #
Q9FXA3
UniProt Comments
Transcription factor that controls embryo growth (PubMed:18567831, PubMed:18849529, PubMed:23318634). Regulates endosperm breakdown and embryonic epidermal development. Regulates the expression of SBT2.4/ALE1 (PubMed:18849529, PubMed:23318634). Involved in embryonic cuticle formation upstream of SBT2.4/ALE1 (PubMed:23318634). Does not seem to be a general regulator of endosperm patterning. May control specific signaling pathways that coordinate embryo invasion and breakdown of surrounding endosperm tissues (PubMed:18849529). Required for the production the embryo sheath, an extracuticular endosperm-derived structure at the surface of the embryo. Acts upstream of KRS (PubMed:28696222).