NCBI Accession #
NP_179742.2
NCBI GenBank Nucleotide #
NM_127719.4
NCBI Official Full Name
SUMO-activating enzyme 2
NCBI Official Symbol
SAE2
NCBI Official Synonym Symbols
ATSAE2; EMB2764; EMBRYO DEFECTIVE 2764; F3K23.23; F3K23_23; SUMO-activating enzyme 2; SUMO-ACTIVATING ENZYME 2
NCBI Protein Information
SUMO-activating enzyme 2
NCBI Summary
Encodes one of the two subunits of the SUMO activation enzyme required during sumolation. Sumolation is a post-translational protein modification process similar to ubiquitination during which a polypeptide (SUMO) is covalently attached to a target protein.
UniProt Synonym Gene Names
EMB2764
UniProt Protein Name
SUMO-activating enzyme subunit 2
UniProt Synonym Protein Names
Protein EMBRYO DEFECTIVE 2764; Ubiquitin-like 1-activating enzyme E1B
UniProt Primary Accession #
Q9SJT1
UniProt Secondary Accession #
Q84YI5; Q8GYC2; Q8LKN2
UniProt Related Accession #
Q9SJT1
UniProt Comments
The dimeric enzyme acts as an E1 ligase for SUMO1 and SUMO2. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.