NCBI Accession #
NP_194380.1
NCBI GenBank Nucleotide #
NM_118783.3
NCBI Official Full Name
chloroplast sulfur E
NCBI Official Symbol
CPSUFE
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA SULFUR E; ATSUFE; chloroplast sulfur E; EMB1374; M3E9.70; M3E9_70; MBRYO DEFECTIVE 1374; SUFE1; SULFUR E 1
NCBI Protein Information
chloroplast sulfur E
NCBI Summary
Sulfur acceptor that interacts with and activates the cysteine desulfurases, AtSufS in plastids and AtNifS1 in mitochondria, and both activations are vital during embryogenesis. Dual localization in mitochondria and chloroplasts. Involved in Fe-S cluster biogenesis in mitochondria and plastids. Expressed in all major tissues, with higher expression in green parts. Its expression is light-dependent and regulated at the mRNA level. Activates the cysteine desulfurase activity of CpNifS for chloroplastic iron-sulfur cluster biogenesis.
UniProt Synonym Gene Names
AtSUFE1
UniProt Protein Name
SufE-like protein 1, chloroplastic/mitochondrial
UniProt Synonym Protein Names
Chloroplastic SufE
UniProt Primary Accession #
Q84W65
UniProt Secondary Accession #
O65584
UniProt Related Accession #
Q84W65
UniProt Comments
Participates in cysteine desulfurization mediated by NFS2 in chloroplast and NIFS1 in mitochondrion (PubMed:16437155). Activates the cysteine desulfurase activity of NFS2 (PubMed:16455656). Cysteine desulfurization mobilizes sulfur from L-cysteine to yield L-alanine and supplies the inorganic sulfur for iron-sulfur (Fe-S) cluster formation. Glutaredoxins regulate SUFE1 activity by inducing its reduction and deglutathionylation (PubMed:24203231).