NCBI Accession #
NP_196232.1
NCBI GenBank Nucleotide #
NM_120696.4
NCBI Official Full Name
sorting nexin 1
NCBI Official Symbol
SNX1
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA SORTING NEXIN 1; ATSNX1; K16F4.11; K16F4_11; sorting nexin 1
NCBI Protein Information
sorting nexin 1
NCBI Summary
Homolog of yeast retromer subunit VPS5. Part of a retromer-like protein complex involved in endosome to lysosome protein transport. In roots it co-localizes with the PIN2 auxin efflux carrier. Involved in endocytic sorting of membrane proteins including PIN2, BOR1 and BRI1.
UniProt Synonym Gene Names
VPS5; AtSNX1
UniProt Protein Name
Sorting nexin 1
UniProt Synonym Protein Names
Vacuolar protein sorting-associated protein 5 homolog
UniProt Primary Accession #
Q9FG38
UniProt Secondary Accession #
Q8RXM2
UniProt Related Accession #
Q9FG38
UniProt Comments
Plays a role in vesicular protein sorting. Acts at the crossroads between the secretory and endocytic pathways. Is involved in the endosome to vacuole protein transport via its interaction with the BLOS1/2 proteins and, as component of the membrane-associated retromer complex, is also involved in endosome-to-Golgi retrograde transport. Required for the auxin-carrier protein PIN2 sorting to the lytic vacuolar pathway and the trafficking of several plasma membrane proteins. Also involved in the efficient sorting of seed storage protein globulin 12S.