NCBI Accession #
NP_198034.2
NCBI GenBank Nucleotide #
NM_122564.5
NCBI Official Full Name
iron-regulated protein 3
NCBI Official Symbol
IREG3
NCBI Official Synonym Symbols
ATIREG3; F2P16.6; F2P16_6; IRON REGULATED 3; iron-regulated protein 3; MAR1; MULTIPLE ANTIBIOTIC RESISTANCE 1; RTS3
NCBI Protein Information
iron-regulated protein 3
NCBI Summary
Mutations in MAR1 confer resistance, while MAR1 overexpression causes hypersensitivity to multiple aminoglycoside antibiotics. Localizes to the chloroplast envelope. MAR1 may act as a plastid transporter involved in cellular iron homeostasis.
UniProt Synonym Gene Names
FPN3; MAR1; RTS3; AtIREG3
UniProt Protein Name
Solute carrier family 40 member 3, chloroplastic
UniProt Synonym Protein Names
Ferroportin-3; Iron-regulated transporter 3; AtIREG3; Protein MULTIPLE ANTIBIOTIC RESISTANCE 1
UniProt Primary Accession #
Q8W4E7
UniProt Secondary Accession #
O04629
UniProt Related Accession #
Q8W4E7
UniProt Comments
Probable plastid transporter that may play a role in iron chelation, storage or sequestration under limiting iron conditions. In presence of exogenous antibiotics, may allow opportunistic entry of multiple aminoglycoside antibiotics into the chloroplast.