NCBI Accession #
NP_001118546.1
NCBI GenBank Nucleotide #
NM_001125074.2
NCBI Official Full Name
SNF1 kinase homolog 10
NCBI Official Symbol
KIN10
NCBI Official Synonym Symbols
AKIN10; SNF1 kinase homolog 10; SNF1-RELATED PROTEIN KINASE; SNF1-RELATED PROTEIN KINASE 1.1; SNRK1.1; T4P13.22; T4P13_22
NCBI Protein Information
SNF1 kinase homolog 10
NCBI Summary
encodes a SNF1-related protein kinase that physically interacts with SCF subunit SKP1/ASK1 and 20S proteosome subunit PAD1. It can also interact with PRL1 DWD-containing protein. Based on in vitro degradation assays and cul4cs and prl1 mutants, there is evidence that AKIN10 is degraded in a proteasome-dependent manner, and that this depends on a CUL4-PRL1 E3 ligase
UniProt Synonym Gene Names
AK21; SKIN10; SNR2; SNRK1.1; AKIN10; AKINalpha2
UniProt Protein Name
SNF1-related protein kinase catalytic subunit alpha KIN10
UniProt Synonym Protein Names
AKIN alpha-2; AKINalpha2
UniProt Primary Accession #
Q38997
UniProt Secondary Accession #
O04728; Q38987; Q39076; Q8RWD2; A6XGR0
UniProt Related Accession #
Q38997
UniProt Comments
Catalytic subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase and in assimilation of nitrogen by phosphorylating nitrate reductase. In vitro, KIN10 exhibits kinase activity on sucrose phosphate synthase and the kinase activity is inhibited by PRL1. May be a subunit of a SCF ubiquitin ligase complex and thus be involved in proteasomal ubiquitination. Phosphorylates GRIK1/SNAK2 and GRIK2/SNAK1 in vitro.