NCBI Accession #
NP_568603.1
NCBI GenBank Nucleotide #
NM_123584.5
NCBI Official Full Name
E3 ubiquitin ligase SCF complex subunit SKP1/ASK1 family protein
NCBI Official Symbol
AT5G42190
NCBI Official Synonym Symbols
Arabidopsis SKP-like 2; ARABIDOPSIS SKP1-LIKE 2; ASK2; MJC20.30; MJC20_30; SKP1B
NCBI Protein Information
E3 ubiquitin ligase SCF complex subunit SKP1/ASK1 family protein
NCBI Summary
Similar to SKP1 in yeast and humans which are involved in mitotic cell cycle control and ubiquitin mediated proteolysis.
UniProt Synonym Gene Names
ASK2; UIP2
UniProt Protein Name
SKP1-like protein 1B
UniProt Synonym Protein Names
SKP1-like 2; UFO-binding protein 2
UniProt Primary Accession #
Q9FHW7
UniProt Secondary Accession #
O65283; Q0WSZ3
UniProt Related Accession #
Q9FHW7
UniProt Comments
Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1), SCF(ADO2), SCF(ADO3) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling. Plays a role during embryogenesis and early postembryonic development, especially during cell elongation and division. Contributes to the correct chromosome segregation during tetrad formation.