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Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2AA1), Recombinant Protein
Cat: RP06864
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2AA1) , partial
Product Gene Name
PP2AA1 recombinant protein
Product Synonym Gene Name
PP2AA1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
65,494 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Serine/threonine-protein phosphatase
NCBI/Uniprot Data
NCBI Accession #
NP_173920.1
NCBI GI #
15222601
NCBI GenBank Nucleotide #
NM_102360.4
NCBI GeneID
839135
NCBI Official Full Name
ARM repeat superfamily protein
NCBI Official Symbol
RCN1
NCBI Official Synonym Symbols
ATB BETA BETA; EER1; ENHANCED ETHYLENE RESPONSE 1; F2J7.19; F2J7_19; PHOSPHOPROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT A; REGA; ROOTS CURL IN NPA; SERINE/THREONINE PROTEIN PHOSPHATASE TYPE 2A REGULATORY SUBUNIT A
NCBI Protein Information
ARM repeat superfamily protein
NCBI Summary
One of three genes encoding phosphoprotein phosphatase 2A regulatory subunit A; Recessive ethylene-response mutant EER1 displays increased ethylene sensitivity in the hypocotyl and stem
UniProt Gene Name
PP2AA1
UniProt Synonym Gene Names
EER1; RCN1; REGA; AtA alpha; PP2A, subunit A, alpha isoform; PR-65 A
UniProt Protein Name
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
UniProt Synonym Protein Names
Protein ROOTS CURL IN NAPHTHYLPHTHALAMIC ACID 1; Protein enhancer of ethylene-response 1
UniProt Primary Accession #
Q38845
UniProt Secondary Accession #
Q38855; Q38952; Q56WI3; Q570B7
UniProt Related Accession #
Q38845
UniProt Comments
The A subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Seems to act as a positive regulator of PP2A catalytic activity. Confers resistance to phosphatase inhibitors such as okadaic acid and cantharidin. Involved during developmental process such as seedling and floral developments, root gravitropism, and stomatal opening regulation. Involved in the regulation of auxin efflux, especially during basipetal (tips to base) auxin transport in roots, and appears to contribute to the perception of auxin efflux inhibitors such as 1-N-naphthylphthalamic acid (NPA) and to semicarbazone I (substituted phenylsemicarbazone of 2-acetylarylcarboxylic acids) (SCB-I). Modulates the magnitude of ethylene response in the hypocotyl and stem, and functions as a general positive transducer of early ABA signaling. The holoenzyme composed of PP2AA1, PP2A4 and B'ZETA or B'ETA acts as negative regulator of plant innate immunity by controlling BAK1 phosphorylation state and activation in surface-localized immune receptor complexes (PubMed:25085430).
For research use only, not for clinical use.