NCBI Accession #
NP_191501.1
NCBI GenBank Nucleotide #
NM_115804.4
NCBI Official Full Name
crinkly4
NCBI Official Synonym Symbols
ACR4; crinkly4
NCBI Protein Information
crinkly4
NCBI Summary
Encodes a membrane localized protein with similarity to receptor kinases which is involved in epidermal cell differentiation. Flowers of mutants have disorganized ovule integument growth and abnormal sepal margins. In the roots, mutants initiate more lateral roots but fewer laterals actually emerge due to defects in lateral root formation. Mutants also display disorganized columella. The root phenotypes can be traced to abnormalities in asymmetric divisions in the pericycle and root apex. Conflicting data regarding the role of the kinase domain- which may or may not be required for function. Complementation studies indicate that the C-terminal domain is also not required for signaling function. May be regulated by protein turnover which is mediated by endocytic processes.
UniProt Synonym Gene Names
AtCR4
UniProt Protein Name
Serine/threonine-protein kinase-like protein ACR4
UniProt Synonym Protein Names
Protein CRINKLY 4; AtCR4
UniProt Primary Accession #
Q9LX29
UniProt Related Accession #
Q9LX29
UniProt Comments
Controls formative cell division in meristems, including root tips and lateral root initiation zones of the pericycle, in response to CLE40 signal. Acts with CLE40p peptide as a ligand-receptor pair in a signal transduction pathway, coordinating movement of the root tip and organization of cell divisions in the root meristem. Required during embryogenesis and development, probably for the differentiation of protoderm and epidermal cells. Involved in the regulation of cellular organization during the development of sepal margins and ovule integument outgrowth. Can phosphorylate ALE2.