Serine/threonine-protein kinase ATM (ATM), Recombinant Protein
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Serine/threonine-protein kinase ATM (ATM), Recombinant Protein

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Cat: RP00134
Size: 0.5 mg (E-Coli)/ 0.05 mg (Baculovirus)/ 0.5 mg (Yeast)/ 0.05 mg (Mammalian-Cell)/ 1 mg (E-Coli)/ 0.1 mg (Baculovirus)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATM (ATM) , partial
Product Gene Name
ATM recombinant protein
Product Synonym Gene Name
ATM
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
YKQLAKSGND DLRQDAVMEQ FFGLVNTFLH NNRDTWKRRL AVRTYKVIPF TPSAGVLEWV DGTIPLGDYL IGSSRSEGAH GRYGIGNWKY PKCREHMSSA KDKRKAFVDV CTNFRPVMHY FFLEKFLQPA DWFVKRLAYT RSVAASSMVG YIVGLGDRHA MNILIDQATA EVVHIDLGVA FEQGLMLKTP ERVPFRLTRD IIDGMGITGV EGVFRRCCEE TLSVMRTNKE ALLTIVEVFI HDPLYKWAL
Sequence Positions
3525-3773; Partial
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
435,114 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Serine-protein kinase

NCBI/Uniprot Data

NCBI Accession #
Q9M3G7.1
NCBI GI #
56748564
NCBI Official Full Name
Serine/threonine-protein kinase ATM
UniProt Gene Name
ATM
UniProt Synonym Gene Names
AtATM
UniProt Protein Name
Serine/threonine-protein kinase ATM
UniProt Synonym Protein Names
Ataxia telangiectasia mutated homolog; AtATM
UniProt Primary Accession #
Q9M3G7
UniProt Secondary Accession #
Q9M4D7; F4JDV3
UniProt Comments
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR) or DNA replication stalling. Plays a central role in the perception and response to both stress-induced damage in somatic cells and developmentally programmed DNA damage during meiosis. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone variant H2AX to form H2AXS139ph at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Involved in transcriptional regulation of RAD51, PARP1, GR1, and LIG4 in response to DNA double strand breaks. Plays a dual role by activating the DNA damage response at dysfunctional telomeres and yet preventing this activation at functional telomeres. Not required for telomere length homeostasis.

For research use only, not for clinical use.