RPM1-interacting protein 4 (RIN4), Recombinant Protein
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RPM1-interacting protein 4 (RIN4), Recombinant Protein

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Cat: RP02285
Size: 0.02 mg (E-Coli)/ 0.1 mg (E-Coli)/ 0.02 mg (Yeast)/ 0.1 mg (Yeast)/ 0.02 mg (Baculovirus)/ 0.02 mg (Mammalian-Cell)/ 1 mg (E-Coli)/ 0.1 mg (Baculovirus)/ 1 mg (Yeast)/ 0.1 mg (Mammalian-Cell)/ 1 mg (Baculovirus)/ 0.5 mg (Mammalian-Cell)
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana RPM1-interacting protein 4 (RIN4)
Product Gene Name
RIN4 recombinant protein
Product Synonym Gene Name
RIN4
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Sequence
MARSNVPKFG NWEAEENVPY TAYFDKARKT RAPGSKIMNP NDPEYNSDSQ SQAPPHPPSS RTKPEQVDTV RRSREHMRSR EESELKQFGD AGGSSNEAAN KRQGRASQNN SYDNKSPLHK NSYDGTGKSR PKPTNLRADE SPEKVTVVPK FGDWDENNPS SADGYTHIFN KVREERSSGA NVSGSSRTPT HQSSRNPNNT SSCCCFGFGG K
Sequence Positions
1-211, Full length protein
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
23,371 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
RPM1-interacting protein

NCBI/Uniprot Data

NCBI Accession #
NP_189143.2
NCBI GI #
30687738
NCBI GenBank Nucleotide #
NM_113411.3
NCBI GeneID
822098
NCBI Official Full Name
RPM1 interacting protein 4
NCBI Official Symbol
RIN4
NCBI Official Synonym Symbols
AtRIN4; RPM1 interacting protein 4
NCBI Protein Information
RPM1 interacting protein 4
NCBI Summary
Encodes a member of the R protein complex and may represent a virulence target of type III pili effector proteins (virulence factors) from bacterial pathogens, which is 'guarded' by R protein complex (RPM1 and RPS2 proteins). RIN4 physically interacts with RPS2 and RPM1 in vivo. Bacterial avirulence (Avr) effectors AvrB, AvrRpm1, and AvrRpt2 induce a mobility shift in RIN4 and expression of AvrRpt2 induces rapid degradation of RIN4. RIN4 contains 2 sites for AvrRpt2 autocleavage, called RCS1 and RCS2. Overexpression of RIN4 inhibits multiple phenotypes associated with AvrRpt2 function and also inhibits PAMP-induced defense signaling. Attached to the plasma membrane at its carboxyl terminus. Cleaved by AvrRpt2 at two PxFGxW motifs, one releasing a large portion of RIN4 from the plasma membrane and both exposing amino-terminal residues that destabilized the carboxyl-terminal cleavage products by targeting them for N-end ubiquitylation and proteasomal degradation. Major virulence target of the TTSE HopF2Pto.
UniProt Gene Name
RIN4
UniProt Protein Name
RPM1-interacting protein 4
UniProt Primary Accession #
Q8GYN5
UniProt Secondary Accession #
Q9LSG9
UniProt Related Accession #
Q8GYN5
UniProt Comments
Essential regulator of plant defense, which plays a central role in resistance in case of infection by a pathogen. It is a common target for both type III avirulence proteins from P.syringae (AvrB, AvrRpm1 and AvrRpt2) and for the plant Resistance (R) proteins RPM1 and RPS2. In strains carrying the appropriate R gene for avirulence proteins of the pathogen, its association with avirulence proteins triggers a defense system including the hypersensitive response, which limits the spread of disease. In contrast, in plants lacking appropriate R genes, its association with avirulence proteins of the pathogen impairs the defense system and leads to the pathogen multiplication.

For research use only, not for clinical use.