NCBI Accession #
NP_195556.1
NCBI GenBank Nucleotide #
NM_120005.4
NCBI Official Full Name
rho guanyl-nucleotide exchange factor 1
NCBI Official Symbol
ROPGEF1
NCBI Official Synonym Symbols
ATROPGEF1; F22I13.200; F22I13_200; KINASE PARTNER PROTEIN-LIKE; KPP-LIKE; rho guanyl-nucleotide exchange factor 1; ROP (rho of plants) guanine nucleotide exchange factor 1
NCBI Protein Information
rho guanyl-nucleotide exchange factor 1
NCBI Summary
Member of the RopGEF (guanine nucleotide exchange factor) family, containing the novel PRONE domain (plant-specific Rop nucleotide exchanger), which is exclusively active towards members of the Rop subfamily, also known as DUF315). Interacts with ROP1 but the whole protein lacks Rho guanyl-nucleotide exchange factor activity in vitro. The DUF315/PRONE domain is sufficient to confer RopGEF catalytic activity.
UniProt Gene Name
ROPGEF1
UniProt Synonym Gene Names
AtRopGEF1; KPP-like
UniProt Protein Name
Rop guanine nucleotide exchange factor 1
UniProt Synonym Protein Names
Kinase partner protein-like; KPP-like; Rho of plants guanine nucleotide exchange factor 1
UniProt Primary Accession #
Q93ZY2
UniProt Secondary Accession #
Q9SVE2
UniProt Related Accession #
Q93ZY2
UniProt Comments
Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP. Acts downstream of PRK2 in the control of polarized pollen tube growth by activating ARAC11/ROP1. In association with ROPGEF4, acts as specific regulator of ARAC10/ROP11 function in ABA-mediated stomatal closure. May play a role in the Rac/Rop-signaling pathway that controls ROS-mediated root hair development.