NCBI Accession #
NP_568396.1
NCBI GenBank Nucleotide #
NM_122064.3
NCBI Official Full Name
RING-box 1
NCBI Official Symbol
RBX1
NCBI Official Synonym Symbols
ATRBX1; F7C8.160; F7C8_160; HRT1; REGULATOR OF CULLINS-1; RING-box 1; RING-BOX 1; ROC1
NCBI Protein Information
RING-box 1
NCBI Summary
Encodes a ring-box 1 like protein and component of the SCF ubiquitinization complex mediating auxin responses. Forms a E3 ubiquitin ligase complex with CUL3A and At1g21780.1 a BTB domain protein.
UniProt Synonym Gene Names
ROC1
UniProt Protein Name
RING-box protein 1a
UniProt Synonym Protein Names
At-Rbx1;1; Protein RING of cullins 1; RBX1-2; RBX1a-At
UniProt Primary Accession #
Q940X7
UniProt Related Accession #
Q940X7
UniProt Comments
Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF complex plays a crucial role in regulating response to auxin and is essential for growth and development. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL1.