NCBI Accession #
NP_201235.4
NCBI GenBank Nucleotide #
NM_125826.5
NCBI Official Full Name
GTP cyclohydrolase II
NCBI Official Synonym Symbols
ARABIDOPSIS THALIANA GTP CYCLOHYDROLASE II; Arabidopsis thaliana riboflavin A1; ATGCH; ATRIBA1; GTP cyclohydrolase II; GTP CYCLOHYDROLASE II; RED FLUORESCENT IN DARKNESS 1; RFD1; RIBA1; riboflavin A1
NCBI Protein Information
GTP cyclohydrolase II
NCBI Summary
encodes GTP cyclohydrolase II that can functionally complement E. coli mutant deficient in this gene. It also has 3,4-dihydroxy-2-butanone-4-phosphate synthase activity which makes it a bifunctional enzyme involved in the formation of the pyrimidine and of the carbohydrate from GTP and ribulose-5-phosphate, respectively
UniProt Synonym Gene Names
RIBBA; AtRIBA1; DHBP synthase
UniProt Protein Name
Bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic
UniProt Synonym Protein Names
3,4-dihydroxy-2-butanone 4-phosphate synthase (EC:4.1.99.12); DHBP synthaseGTP cyclohydrolase-2 (EC:3.5.4.25)Alternative name(s):GTP cyclohydrolase II
UniProt Primary Accession #
P47924
UniProt Secondary Accession #
Q9SBA8
UniProt Related Accession #
P47924
UniProt Comments
Involved in riboflavin biosynthesis. Catalyzes both the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate and the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. RIBA2 and RIBA3 together are not able to complement the loss of function of RIBA1.