NCBI Accession #
NP_001328027.1
NCBI GenBank Nucleotide #
NM_001341366.1
NCBI Official Full Name
NPR1-like protein 4
NCBI Official Symbol
NPR4
NCBI Official Synonym Symbols
ATNPR4; NPR1-like protein 4; T16H5.20; T16H5_20
NCBI Protein Information
NPR1-like protein 4
NCBI Summary
Encodes NPR4, a ankyrin repeat BTB/POZ domain-containing protein with 36% sequence identity with NPR1. Mutants are more susceptible to the bacterial pathogen Pseudomonas syringe pv. tomato DC3000 and to the fungal pathogen Erysiphe cichoracearum, but do not differ markedly from wild type in interaction with virulent and avirulent strains of the oomycete Peronospora parasitica. NPR4 is required for basal defense against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways. NPR3 and NPR4 are receptors for the immune signal salicylic acid.
UniProt Protein Name
Regulatory protein NPR4
UniProt Synonym Protein Names
BTB/POZ domain-containing protein NPR4
UniProt Primary Accession #
Q5ICL9
UniProt Secondary Accession #
O81848
UniProt Related Accession #
Q5ICL9
UniProt Comments
May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Involved in the regulation of basal defense responses against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways.