NCBI Accession #
NP_191462.1
NCBI GenBank Nucleotide #
NM_115765.4
NCBI Official Full Name
MATE efflux family protein
NCBI Official Symbol
TT12
NCBI Official Synonym Symbols
A. THALIANA TRANSPARENT TESTA; ATTT12; TRANSPARENT TESTA 12
NCBI Protein Information
MATE efflux family protein
NCBI Summary
Encodes a proton antiporter. Involved in the transportation of proanthocyanidin precursors into the vacuole. In vitro transport experiments showed that cyanidin-3-O-glucoside (anthocyanin) was an effective substrate, whereas the proanthocyanidin precursor epicatechin was not transported. However catechin-3-O-glucoside inhibited anthocyanin transport in a dose-dependent manner suggesting that glycosylated epicatechin is the in vivo substrate. Recessive mutation has strong reduction of proanthocyanidin deposition in vacuoles and has reduced dormancy. Expressed in the endothelium of ovules and developing seeds.
UniProt Synonym Gene Names
MATE protein 41Curated
UniProt Protein Name
Protein DETOXIFICATION 41
UniProt Synonym Protein Names
Multidrug and toxic compound extrusion protein 41
UniProt Primary Accession #
Q9LYT3
UniProt Related Accession #
Q9LYT3
UniProt Comments
Acts as a flavonoid/H+-antiporter that control the vacuolar sequestration of flavonoids in the seed coat endothelium (PubMed:11283341, PubMed:17601828). Could transport the anthocyanin cyanidin-3-O-glucoside (PubMed:17601828) and epicatechin 3'-O-glucoside (PubMed:19684242) in vitro.