NCBI Accession #
NP_001331491.1
NCBI GenBank Nucleotide #
NM_001343817.1
NCBI Official Full Name
XS domain-containing protein / XS zinc finger domain-containing protein-like protein
NCBI Official Symbol
SGS3
NCBI Official Synonym Symbols
ATSGS3; MQM1.17; MQM1_17; SUPPRESSOR OF GENE SILENCING 3
NCBI Protein Information
XS domain-containing protein / XS zinc finger domain-containing protein-like protein
NCBI Summary
Required for posttranscriptional gene silencing and natural virus resistance.SGS3 is a member of an 'unknown' protein family. Members of this family have predicted coiled coiled domains suggesting oligomerization and a potential zinc finger domain. Involved in the production of trans-acting siRNAs, through direct or indirect stabilization of cleavage fragments of the primary ta-siRNA transcript. Acts before RDR6 in this pathway.
UniProt Synonym Gene Names
AtSGS3
UniProt Protein Name
Protein SUPPRESSOR OF GENE SILENCING 3
UniProt Primary Accession #
Q9LDX1
UniProt Related Accession #
Q9LDX1
UniProt Comments
Required for post-transcriptional gene silencing and natural virus resistance. May bind nucleic acids and is essential for the biogenesis of trans-acting siRNAs but is not required for silencing induced by IR-PTGS. Involved in the juvenile-to-adult transition regulation. In case of begomoviruses infection, it is targeted by the viral protein V2 leading to suppression of post-transcriptional gene silencing.