NCBI Accession #
NP_181378.2
NCBI GenBank Nucleotide #
NM_129400.3
NCBI Official Full Name
SCAR homolog 2
NCBI Official Symbol
SCAR2
NCBI Official Synonym Symbols
ATSCAR2; DIS3; IRREGULAR TRICHOME BRANCH1; IRREGULAR TRICHOME BRANCH1; ITB1; SCAR homolog 2; SCAR HOMOLOG 2; T19C21.7; T19C21_7; WAVE4
NCBI Protein Information
SCAR homolog 2
NCBI Summary
Encodes a subunit of the WAVE complex. The WAVE complex is required for activation of ARP2/3 complex which functions in actin microfilament nucleation and branching. Mutations cause defects in both the actin and microtubule cytoskeletons that result in aberrant epidermal cell expansion. itb1 mutants showed irregularities in trichome branch positioning and expansion. The SHD domain of this protein binds to BRK1 and overexpression of the SHD domain results in a dominant negative phenotype.
UniProt Synonym Gene Names
DIS3; ITB1; WAVE4; AtSCAR2
UniProt Protein Name
Protein SCAR2
UniProt Synonym Protein Names
Protein DISTORTED 3; Protein IRREGULAR TRICHOME BRANCH 1; Protein WAVE4
UniProt Primary Accession #
Q5XPJ9
UniProt Secondary Accession #
O80907
UniProt Related Accession #
Q5XPJ9
UniProt Comments
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. Regulates trichome branch positioning and expansion.