Protein HIRA (HIRA), Recombinant Protein
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Protein HIRA (HIRA), Recombinant Protein

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Cat: RP03105
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:

Product Info

Full Product Name
Recombinant Arabidopsis thaliana Protein HIRA (HIRA) , partial
Product Gene Name
HIRA recombinant protein
Product Synonym Gene Name
HIRA
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
112,390 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Protein

NCBI/Uniprot Data

NCBI Accession #
NP_001319681.1
NCBI GI #
1063708320
NCBI GenBank Nucleotide #
NM_001339149.1
NCBI GeneID
823578
NCBI Official Full Name
histone chaperone HIRA-like protein
NCBI Official Symbol
HIRA
NCBI Official Synonym Symbols
homolog of histone chaperone HIRA
NCBI Protein Information
histone chaperone HIRA-like protein
NCBI Summary
Encodes a nuclear localized WD-repeat containing protein involved in negative regulation of knox gene expression via epigenetic mechanism of chromatin re-organization. Interacts physically and genetically with AS1. Expressed in meristem and leaf primordia. Homozygous mutants are embryo lethal. Phenotype of cosuppressed lines is variable but show effects on leaf development similar to as1/as2.
UniProt Gene Name
HIRA
UniProt Protein Name
Protein HIRA
UniProt Synonym Protein Names
Histone regulator protein
UniProt Primary Accession #
Q9LXN4
UniProt Secondary Accession #
F4J343
UniProt Related Accession #
Q9LXN4
UniProt Comments
Histone chaperone involved in maintining knox genes silencing throughout leaf development (PubMed:16243907). Involved in heterochromatic and euchromatic gene silencing, especially upon salt stress (PubMed:25600486). Involved in gene expression reprogramming during dedifferentiation probably by modifying histone H3.3 recruitment at the nucleolus (PubMed:25086063, PubMed:25600486). Contributes to maintenance of silencing of pericentromeric repeats and certain transposons (PubMed:25600486).

For research use only, not for clinical use.