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Protein DAMAGED DNA-BINDING 2 (DDB2), Recombinant Protein
Cat: RP02906
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Protein DAMAGED DNA-BINDING 2 (DDB2) , partial
Product Gene Name
DDB2 recombinant protein
Product Synonym Gene Name
DDB2
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
62,829 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Protein DAMAGED DNA-BINDING
NCBI/Uniprot Data
NCBI Accession #
NP_200684.2
NCBI GI #
42568637
NCBI GenBank Nucleotide #
NM_125263.5
NCBI GeneID
835990
NCBI Official Full Name
damaged DNA binding 2
NCBI Official Symbol
DDB2
NCBI Official Synonym Symbols
damaged DNA binding 2; MZN1.20; MZN1_20
NCBI Protein Information
damaged DNA binding 2
NCBI Summary
Encodes a DDB1a interacting protein DDB2 required for UV-B tolerance and genomic integrity.
UniProt Gene Name
DDB2
UniProt Protein Name
Protein DAMAGED DNA-BINDING 2
UniProt Synonym Protein Names
UV-damaged DNA-binding protein 2
UniProt Primary Accession #
Q6NQ88
UniProt Secondary Accession #
Q9LUY5
UniProt Related Accession #
Q6NQ88
UniProt Comments
May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex including DDB1A and CUL4 . Required for DNA repair. Binds to DDB1A to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair.
For research use only, not for clinical use.