NCBI Accession #
NP_174471.2
NCBI GenBank Nucleotide #
NM_102925.3
NCBI Official Full Name
DZC (Disease resistance/zinc finger/chromosome condensation-like region) domain containing protein
NCBI Official Synonym Symbols
BREVIS RADIX; F5M6.11; F5M6_11; NIP3;1; NLM9; NOD26-like intrinsic protein 3;1
NCBI Protein Information
DZC (Disease resistance/zinc finger/chromosome condensation-like region) domain containing protein
NCBI Summary
Belongs to five-member BRX gene family. Arabidopsis BRX genes share high levels of similarity among each others, with several conserved domains. The most distinct is BRX domain - highly conserved in all BRX genes among distantly related species. This protein-protein interaction domain is required and sufficient for BRX activity. BRX encodes a key regulator of cell proliferation and elongation in the root, which has been implicated in the brassinosteroid (BR) pathway as well as regulation of auxin-responsive gene expression. Also involved in cytokinin-mediated inhibition of lateral root initiation. A loss-of-function allele, named brx-2 in Rodrigues et al. (2009) Plant Physiol. but changed to brx-3 to resolve nomenclature conflict (Li et al. Planta 2009:229(3):593-603), shows enhanced response to ABA-mediated inhibition of root growth.
UniProt Synonym Gene Names
AtBRX
UniProt Protein Name
Protein BREVIS RADIX
UniProt Primary Accession #
Q17TI5
UniProt Secondary Accession #
Q17TI6; Q84JB6; Q9C6S9
UniProt Related Accession #
Q17TI5
UniProt Comments
Acts as a regulator of cell proliferation and elongation in the root and shoot. Probable transcription regulator. Regulated by the auxin response factor ARF5. Polarly localized in vascular cells and subject to endocytic recycling. Required for CPD expression and for correct nuclear auxin response. Mediates cross-talk between the auxin and brassinosteroid pathways. BRX is a target for auxin-induced, proteasome-mediated degradation.