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Protein argonaute 2 (AGO2), Recombinant Protein
Cat: RP02702
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Protein argonaute 2 (AGO2) , partial
Product Gene Name
AGO2 recombinant protein
Product Synonym Gene Name
AGO2
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
113,423 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Protein argonaute
NCBI/Uniprot Data
NCBI Accession #
NP_174413.2
NCBI GI #
145336300
NCBI GenBank Nucleotide #
NM_102866.3
NCBI GeneID
840016
NCBI Official Full Name
Argonaute family protein
NCBI Official Symbol
AGO2
NCBI Official Synonym Symbols
argonaute 2; AtAGO2; T19E23.7; T19E23_7
NCBI Protein Information
Argonaute family protein
NCBI Summary
Encodes Argonaute gene that binds viral siRNAs and is involved in antiviral defense response. Regulates innate immunity.
UniProt Gene Name
AGO2
UniProt Protein Name
Protein argonaute 2
UniProt Primary Accession #
Q9SHF3
UniProt Secondary Accession #
Q8GX33
UniProt Related Accession #
Q9SHF3
UniProt Comments
Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Associates mainly with siRNAs of 21 nucleotide in length and preferentially recruits small RNAs with a 5' terminal adenosine. Probably involved in antiviral RNA silencing. Associates with siRNA derived from cucumber mosaic virus (CMV). Targeted by turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO2 function in RNA silencing. Required to direct NERD-dependent DNA methylation and silencing.
For research use only, not for clinical use.